Ferroptosis in infection, inflammation, and immunity

Author:

Chen Xin12ORCID,Kang Rui3ORCID,Kroemer Guido45678ORCID,Tang Daolin13ORCID

Affiliation:

1. Guangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modification and Degradation, The Third Affiliated Hospital, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, China

2. Affiliated Cancer Hospital & Institute of Guangzhou Medical University, Guangzhou, China

3. Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX, USA

4. Centre de Recherche des Cordeliers, Equipe labellisée par la Ligue contre le cancer, Université de Paris, Sorbonne Université, Institut national de la santé et de la recherche médicale U1138, Institut Universitaire de France, Paris, France

5. Metabolomics and Cell Biology Platforms, Gustave Roussy Cancer Campus, Villejuif, France

6. Pôle de Biologie, Hôpital Européen Georges Pompidou, Assistance Publique–Hôpitaux de Paris, Paris, France

7. Suzhou Institute for Systems Biology, Chinese Academy of Sciences, Suzhou, China

8. Department of Women's and Children's Health, Karolinska University Hospital, Stockholm, Sweden

Abstract

Ferroptosis is a type of regulated necrosis that is triggered by a combination of iron toxicity, lipid peroxidation, and plasma membrane damage. The upstream inducers of ferroptosis can be divided into two categories (biological versus chemical) and activate two major pathways (the extrinsic/transporter versus the intrinsic/enzymatic pathways). Excessive or deficient ferroptotic cell death is implicated in a growing list of physiological and pathophysiological processes, coupled to a dysregulated immune response. This review focuses on new discoveries related to how ferroptotic cells and their spilled contents shape innate and adaptive immunity in health and disease. Understanding the immunological characteristics and activity of ferroptotic death not only illuminates an intersection between cell death and immunity but may also lead to the development of novel treatment approaches for immunopathological diseases.

Funder

Agence Nationale de la Recherche

Association pour la Recherche sur le Cancer

Cancéropôle Ile de France

Chancellerie des Universités de Paris

Elior

European Research Area Network on Cardiovascular Diseases

Fondation Carrefour

Fondation pour la Recherche Médicale

Gustave Roussy Odyssea

Horizon 2020 Framework Programme

High-end Foreign Expert Program in China

Institut national de la santé et de la recherche médicale

Institut National du Cancer

Institut Universitaire de France

LabEx Immuno-Oncology

LeDucq Foundation

Ligue Contre le Cancer

Recherche Hospitalo-Universitaire Torino Lumière

Seerave Foundation

SIRIC Stratified Oncology Cell DNA Repair and Tumor Immune Elimination

SIRIC Cancer Research and Personalized Medicine

Publisher

Rockefeller University Press

Subject

Immunology,Immunology and Allergy

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