THE QUANTITATIVE RELATIONSHIP BETWEEN IMMUNE SERUM AND INFECTIVE DOSE OF PARASITES AS DEMONSTRATED BY THE PROTECTION TEST IN MONKEY MALARIA

Author:

Coggeshall Lowell T.1,Eaton Monroe D.1

Affiliation:

1. From the Laboratories of the International Health Division, The Rockefeller Foundation, New York

Abstract

The minimal infective dose of Plasmodium knowlesi for rhesus monkeys was found in this study to be between 1 and 10 parasites when injected intraperitoneally. As the dose of parasites is increased, the length of time prior to the appearance of circulating parasites is decreased. However, the severity of the infection once it is established is independent of the initial dose of parasites. In passive protection experiments a quantitative relationship was demonstrated between the number of parasites in the inoculum and the effective amount of immune serum given at the time of infection and in equal doses daily for 9 days thereafter. The smaller the inoculum, the less the quantity of immune serum required to prevent the death of the animal. When relatively large amounts of immune sera and small numbers of parasites were used in the protection experiment, infection was prevented.

Publisher

Rockefeller University Press

Subject

Immunology,Immunology and Allergy

Cited by 27 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. The role ofPlasmodium knowlesiin the history of malaria research;Parasitology;2016-11-10

2. The Mechanism Involved in Acquired Immunity to Tuberculosis;Ciba Foundation Symposium - Experimental Tuberculosis: Bacillus and Host (with an Addendum on Leprosy);2008-05-30

3. Plasmodium gallinaceum: Variation in susceptibility of dove erythrocyte;Experimental Parasitology;1971-12

4. Passive immunity in Plasmodium knowlesi malaria;Transactions of the Royal Society of Tropical Medicine and Hygiene;1970-01

5. Immunological Aspects of Malaria Infection;Advances in Immunology Volume 11;1969

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