Author:
Grabstein K,Eisenman J,Mochizuki D,Shanebeck K,Conlon P,Hopp T,March C,Gillis S
Abstract
Murine B cell stimulating factor 1 (BSF-1) was purified to homogeneity from supernatants of a stimulated thymoma cell line. A protein of 18.4 kD with a unique N-terminal amino acid sequence was identified. BSF-1 had a sp act of at least 3.28 X 10(8) U/mg. In addition to its B cell-stimulatory activity, BSF-1 also stimulated the proliferation of several IL-2- and IL-3-dependent cell lines. We conclude that BSF-1 is both a growth factor and a differentiation factor. Finally, these results also suggest additional biologic properties of BSF-1 on lineages besides B lymphocytes.
Publisher
Rockefeller University Press
Subject
Immunology,Immunology and Allergy
Cited by
174 articles.
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