Macrophages induce differentiation of plasma cells through CXCL10/IP-10-Reference-Cited by-同舟云学术

Macrophages induce differentiation of plasma cells through CXCL10/IP-10

Published:2012-09-17 Issue:10 Volume:209 Page:1813-1823
ISSN:1540-9538
Container-title:Journal of Experimental Medicine
language:en
Short-container-title:

Author:

Xu Wei¹²,Joo HyeMee¹,Clayton Sandra¹,Dullaers Melissa¹,Herve Marie-Cecile¹,Blankenship Derek¹,De La Morena Maria Teresa³,Balderas Robert⁴,Picard Capucine⁵,Casanova Jean-Laurent⁶,Pascual Virginia¹,Oh SangKon¹,Banchereau Jacques¹

Affiliation:

1. Baylor Institute for Immunology Research, Dallas, TX 75204

2. Pharma Research and Early Development, Hoffmann–La Roche Inc., Nutley, NJ 07110

3. Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390

4. BD Biosciences, San Diego, CA 92121

5. Laboratory of Human Genetics of Infectious Diseases, Necker Division, Necker Medical School, National Institute of Health and Medical Research (INSERM) U980, Paris Descartes University, Sorbonne Paris Cité, Necker Medicine Faculty, 75015 Paris, France

6. St. Giles Laboratory of Human Genetics of Infectious Diseases, The Rockefeller University, New York, NY 10065

Abstract

In tonsils, CD138+ plasma cells (PCs) are surrounded by CD163+ resident macrophages (Mϕs). We show here that human Mϕs (isolated from tonsils or generated from monocytes in vitro) drive activated B cells to differentiate into CD138+CD38++ PCs through secreted CXCL10/IP-10 and VCAM-1 contact. IP-10 production by Mϕs is induced by B cell–derived IL-6 and depends on STAT3 phosphorylation. Furthermore, IP-10 amplifies the production of IL-6 by B cells, which sustains the STAT3 signals that lead to PC differentiation. IP-10–deficient mice challenged with NP-Ficoll show a decreased frequency of NP-specific PCs and lower titers of antibodies. Thus, our results reveal a novel dialog between Mϕs and B cells, in which IP-10 acts as a PC differentiation factor.

Publisher

Rockefeller University Press

Subject

Immunology,Immunology and Allergy

Link

http://rupress.org/jem/article-pdf/209/10/1813/1206426/jem_20112142.pdf

Reference60 articles.

1. B1b lymphocytes confer T cell-independent long-lasting immunity;Alugupalli;Immunity.,2004

2. Generation of memory B cells and plasma cells in vitro;Arpin;Science.,1995

3. B cell-intrinsic signaling through IL-21 receptor and STAT3 is required for establishing long-lived antibody responses in humans;Avery;J. Exp. Med.,2010

4. The who, how and where of antigen presentation to B cells;Batista;Nat. Rev. Immunol.,2009

5. B-cell activation by membrane-bound antigens is facilitated by the interaction of VLA-4 with VCAM-1;Carrasco;EMBO J.,2006

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