THE HALF-LIFE OF HOMOLOGOUS GAMMA GLOBULIN (ANTIBODY) IN SEVERAL SPECIES

Author:

Dixon Frank J.1,Talmage David W.1,Maurer Paul H.1,Deichmiller Maria1

Affiliation:

1. From the Pathology Department, University of Pittsburgh School of Medicine, Pittsburgh

Abstract

1. The half-lives of homologous gamma globulins labelled with I131 agree well with the half-lives of passively administered homologous antibodies and provide a simple, quantitative tool for the determination of antibody half-life when immunochemical techniques are difficult to apply. 2. The half-lives of gamma globulin or antibody vary markedly from species to species and apparently even among age groups within a species. 3. The half-lives of gamma globulin or antibody seem to be dependent, at least in part, on the metabolic rate of the host.

Publisher

Rockefeller University Press

Subject

Immunology,Immunology and Allergy

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