Affiliation:
1. Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, Cleveland, OH
Abstract
IL-17, a potent proinflammatory cytokine, has been shown to intimately contribute to the formation, growth, and metastasis of a wide range of malignancies. Recent studies implicate IL-17 as a link among inflammation, wound healing, and cancer. While IL-17–mediated production of inflammatory mediators mobilizes immune-suppressive and angiogenic myeloid cells, emerging studies reveal that IL-17 can directly act on tissue stem cells to promote tissue repair and tumorigenesis. Here, we review the pleotropic impacts of IL-17 on cancer biology, focusing how IL-17–mediated inflammatory response and mitogenic signaling are exploited to equip its cancer-promoting function and discussing the implications in therapies.
Funder
National Institutes of Health
National Multiple Sclerosis Society
Publisher
Rockefeller University Press
Subject
Immunology,Immunology and Allergy
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