Loss of the interleukin-6 receptor causes immunodeficiency, atopy, and abnormal inflammatory responses-Reference-Cited by-同舟云学术

Loss of the interleukin-6 receptor causes immunodeficiency, atopy, and abnormal inflammatory responses

Published:2019-06-24 Issue:9 Volume:216 Page:1986-1998
ISSN:0022-1007
Container-title:Journal of Experimental Medicine
language:en
Short-container-title:

Author:

Spencer Sarah¹²^ORCID,Köstel Bal Sevgi³⁴^ORCID,Egner William⁵⁶,Lango Allen Hana⁷⁸^ORCID,Raza Syed I.⁹,Ma Chi A.¹⁰,Gürel Meltem¹¹,Zhang Yuan¹⁰^ORCID,Sun Guangping¹⁰,Sabroe Ruth A.¹²,Greene Daniel⁷⁸¹³,Rae William²,Shahin Tala³⁴,Kania Katarzyna¹¹^ORCID,Ardy Rico Chandra³⁴^ORCID,Thian Marini³⁴¹⁴¹⁵^ORCID,Staples Emily²,Pecchia-Bekkum Annika²,Worrall William P.M.²^ORCID,Stephens Jonathan⁷⁸¹⁶,Brown Matthew⁷⁸¹⁶,Tuna Salih⁷⁸¹⁶,York Melanie⁵⁶^ORCID,Shackley Fiona⁵⁶,Kerrin Diarmuid¹⁷,Sargur Ravishankar⁵⁶^ORCID,Condliffe Alison⁵⁶^ORCID,Tipu Hamid Nawaz¹⁸^ORCID,Kuehn Hye Sun¹⁹,Rosenzweig Sergio D.¹⁹,Turro Ernest⁷⁸¹³¹⁶^ORCID,Tavaré Simon¹¹²⁰²¹^ORCID,Thrasher Adrian J.²²^ORCID,Jodrell Duncan Ian²³^ORCID,Smith Kenneth G.C.²^ORCID,Boztug Kaan³⁴¹⁴¹⁵²⁴^ORCID,Milner Joshua D.¹⁰^ORCID,Thaventhiran James E.D.¹²¹¹^ORCID

Affiliation:

1. Medical Research Council Toxicology Unit, University of Cambridge, Cambridge, UK

2. Department of Medicine, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK

3. Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases, Vienna, Austria

4. CeMM Research Center for Molecular Medicine, Austrian Academy of Sciences, Vienna, Austria

5. Sheffield Teaching Hospitals National Health Service Trust, Sheffield, UK

6. Department of Infection Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, UK

7. Department of Haematology, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK

8. National Institute for Health Research BioResource, Cambridge University Hospitals, Cambridge Biomedical Campus, Cambridge, UK

9. Department of Biochemistry, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan

10. Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD

11. Cancer Research UK Cambridge Institute, Cambridge Biomedical Campus, Cambridge, UK

12. Department of Dermatology, Sheffield Teaching Hospitals National Health Service Trust, Sheffield, UK

13. Medical Research Council Biostatistics Unit, Cambridge Biomedical Campus, Cambridge, UK

14. Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria

15. St. Anna Kinderspital and Children’s Cancer Research Institute, Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria

16. National Health Service Blood and Transplant Cambridge, Cambridge Biomedical Campus, Cambridge, UK

17. Barnsley Hospitals National Health Service Foundation Trust, Barnsley, UK

18. Immunology Department, Armed Forces Institute of Pathology, Rawalpindi, Pakistan

19. Department of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, MD

20. Herbert and Florence Irving Institute for Cancer Dynamics, Columbia University, New York, NY

21. New York Genome Center, New York, NY

22. Molecular and Cellular Immunology Section, University College London Great Ormond Street Institute of Child Health, Great Ormond Street Hospital National Health Service Trust, London, UK

23. Department of Oncology, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK

24. Vienna Center for Rare and Undiagnosed Diseases, Vienna, Austria

Abstract

IL-6 excess is central to the pathogenesis of multiple inflammatory conditions and is targeted in clinical practice by immunotherapy that blocks the IL-6 receptor encoded by IL6R. We describe two patients with homozygous mutations in IL6R who presented with recurrent infections, abnormal acute-phase responses, elevated IgE, eczema, and eosinophilia. This study identifies a novel primary immunodeficiency, clarifying the contribution of IL-6 to the phenotype of patients with mutations in IL6ST, STAT3, and ZNF341, genes encoding different components of the IL-6 signaling pathway, and alerts us to the potential toxicity of drugs targeting the IL-6R.

Funder

Medical Research Council

European Research Council

Austrian Science Fund

National Institute of Allergy and Infectious Diseases

NIH

Wellcome Trust

NIHR

University College London

Wellcome

Cancer Research UK

Austrian Academy of Sciences