Targeting interleukin-17 in chronic inflammatory disease: A clinical perspective

Author:

Zwicky Pascale1ORCID,Unger Susanne1ORCID,Becher Burkhard1ORCID

Affiliation:

1. Institute of Experimental Immunology, Department of Inflammation Research, University of Zurich, Zurich, Switzerland

Abstract

Chronic inflammatory diseases like psoriasis, Crohn’s disease (CD), multiple sclerosis (MS), rheumatoid arthritis (RA), and others are increasingly recognized as disease entities, where dysregulated cytokines contribute substantially to tissue-specific inflammation. A dysregulation in the IL-23/IL-17 axis can lead to inflammation of barrier tissues, whereas its role in internal organ inflammation remains less clear. Here we discuss the most recent developments in targeting IL-17 for the treatment of chronic inflammation in preclinical models and in patients afflicted with chronic inflammatory diseases.

Funder

Swiss National Science Foundation

European Union FP7 Project ATECT

European Union H2020 Project IPC

University Research Priority Project Translational Cancer Research

Publisher

Rockefeller University Press

Subject

Immunology,Immunology and Allergy

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