Affiliation:
1. Institute of Experimental Immunology, Department of Inflammation Research, University of Zurich, Zurich, Switzerland
Abstract
Chronic inflammatory diseases like psoriasis, Crohn’s disease (CD), multiple sclerosis (MS), rheumatoid arthritis (RA), and others are increasingly recognized as disease entities, where dysregulated cytokines contribute substantially to tissue-specific inflammation. A dysregulation in the IL-23/IL-17 axis can lead to inflammation of barrier tissues, whereas its role in internal organ inflammation remains less clear. Here we discuss the most recent developments in targeting IL-17 for the treatment of chronic inflammation in preclinical models and in patients afflicted with chronic inflammatory diseases.
Funder
Swiss National Science Foundation
European Union FP7 Project ATECT
European Union H2020 Project IPC
University Research Priority Project Translational Cancer Research
Publisher
Rockefeller University Press
Subject
Immunology,Immunology and Allergy
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