Affiliation:
1. From the Department of Experimental Pathology, Scripps Clinic and Research Foundation, La Jolla, California 92037
Abstract
Early, after in utero infection with LCM virus, SWR/J and HA/ICR mice developed manifestations of immune complex disease. Observations based on nursing such mice with virus-infected, immune, or noninfected mouse mothers indicated that maternal antiviral antibody was responsible for the early immune complex glomerulonephritis. Despite comparable viral persistance, in utero-infected offspring failed to develop glomerulonephritis when nursed by noninfected mouse mothers, but did when suckled by virus-infected mouse mothers. Nursing by mouse mothers carrying high titers of anti-LCM viral antibody markedly enhanced the Ig glomerular deposits and the resultant nephritis.
Publisher
Rockefeller University Press
Subject
Immunology,Immunology and Allergy
Cited by
27 articles.
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