ENHANCEMENT OF ANTIBIOTIC ACTIVITY OF COLICINE K AND ALTERATION OF SEROLOGICAL PROPERTIES OF COLICINE K AND ENDOTOXINS

Author:

van Vunakis Helen1,Ruffilli Anna1,Levine Lawrence1

Affiliation:

1. From the Graduate Department of Biochemistry, Brandeis University, Waltham, Massachusetts

Abstract

Hemoglobin, its chains, and myoglobin enhance the antibiotic activity of colicine K. These proteins also interact with colicine K and other O antigens to alter their serological activity. The hemoglobin proteins did not alter the serological activities of three Pneumococcus polysaccharides or T4 bacteriophage DNA antigens but did alter the antigenic activity of fetuin. Interaction of hemoglobin and colicine K resulted in a retardation of colicine K antibiotic moiety as measured by gel filtration but did not affect the gel filtration properties of the lipopolysaccharide moiety.

Publisher

Rockefeller University Press

Subject

Immunology,Immunology and Allergy

Cited by 5 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Colicinogeny and related phenomena;Bacteriological Reviews;1975-12

2. COLICINOGENY AND RELATED PHENOMENA;BACTERIOL REV;1975

3. General Characteristics;Bacterial Endotoxins;1971

4. In Vitro and In Vivo Characterization of Pyocin;Journal of Bacteriology;1967-06

5. Alteration and Restoration of Endotoxin Activity after Complexing with Plasma Proteins;Journal of Bacteriology;1966-10

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