Author:
Corte G,Moretta A,Cosulich M E,Ramarli D,Bargellesi A
Abstract
The products of the DC locus have been shown to be structurally different from those of the DR locus. In this paper it is shown that, unlike anti-DR antibodies, a monoclonal antibody directed against DC1 does not affect proliferation of T cells in response to alloantigens or soluble antigens or production of Ig in a pokeweed mitogen-stimulated in vitro culture. However, the anti-DC1 inhibits the generation of effector T cells mediating specific cytolytic activity, whereas no inhibitory effect can be observed on natural killer and antibody-dependent cytotoxic cell activities.
Publisher
Rockefeller University Press
Subject
Immunology,Immunology and Allergy
Cited by
59 articles.
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