Graft-versus-host disease in cyclosporin A-treated rats after syngeneic and autologous bone marrow reconstitution.-Reference-Cited by-同舟云学术

Graft-versus-host disease in cyclosporin A-treated rats after syngeneic and autologous bone marrow reconstitution.

Published:1983-07-01 Issue:1 Volume:158 Page:1-8
ISSN:0022-1007
Container-title:Journal of Experimental Medicine
language:en
Short-container-title:

Author:

Glazier A,Tutschka P J,Farmer E R,Santos G W

Abstract

Lethally irradiated rats treated with cyclosporin A (CsA) for 20-40 d develop classic graft-versus-host disease (GVHD) when reconstituted with syngeneic or autologous bone marrow, upon discontinuation of CsA, whereas normal rats do not. Syngeneic GVHD may be transferred to irradiated but not normal syngeneic recipients. Normal spleen cells fail to prevent the development or adoptive transfer of syngeneic GVHD.

Publisher

Rockefeller University Press

Subject

Immunology,Immunology and Allergy

Link

http://rupress.org/jem/article-pdf/158/1/1/1093555/1.pdf

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