Lineage-Restricted Function of Nuclear Factor κB–Inducing Kinase (Nik) in Transducing Signals via Cd40-Reference-Cited by-同舟云学术

Lineage-Restricted Function of Nuclear Factor κB–Inducing Kinase (Nik) in Transducing Signals via Cd40

Published:2000-01-17 Issue:2 Volume:191 Page:381-386
ISSN:0022-1007
Container-title:Journal of Experimental Medicine
language:en
Short-container-title:

Author:

Garceau Norman¹,Kosaka Yoko¹,Masters Sally¹,Hambor John²,Shinkura Reiko³,Honjo Tasuku³,Noelle Randolph J.¹

Affiliation:

1. Department of Microbiology, Dartmouth Medical School, Lebanon, New Hampshire 03756

2. Department of Molecular Sciences, Pfizer Central Research, Groton, Connecticut 06340

3. Department of Medical Chemistry, Kyoto University, Kyoto, 606-8501, Japan

Abstract

CD40 signaling in B cells and dendritic cells (DCs) is critical for the development of humoral and cell-mediated immunity, respectively. Nuclear factor κB (NF-κB)–inducing kinase (NIK) has been implicated as a central transducing kinase in CD40-dependent activation. Here, we show that although NIK is essential for B cell activation, it is dispensable for activation of DCs. Such data provide compelling evidence that different intermediary kinases are used by different cellular lineages to trigger NF-κB activation via CD40.

Publisher

Rockefeller University Press

Subject

Immunology,Immunology and Allergy

Link

http://rupress.org/jem/article-pdf/191/2/381/1125094/99-1702.pdf

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