Affiliation:
1. Department of Genetics and Pathology, Uppsala University, S-75185 Uppsala, Sweden
Abstract
Receptors for immunoglobulin (Ig)G (FcγRs) are important for the antibody-mediated effector functions of the immune system. FcγRI and FcγRIII trigger cell activation through a common γ chain, whereas FcγRII acts as a negative regulator of antibody production and immune complex–triggered activation. Here we describe the in vivo consequences of FcγR deficiency in a mouse model of human rheumatoid arthritis. FcRγ chain–deficient mice on arthritis-susceptible DBA/1 background were immunized with collagen for induction of collagen-induced arthritis. The DBA/1 mice lacking FcRγ chain were protected from collagen-induced arthritis in contrast to wild-type mice, although both groups produced similar levels of IgG anticollagen antibodies. In comparison, DBA/1 mice lacking FcγRII developed an augmented IgG anticollagen response and arthritis. These observations suggest a crucial role of FcγRI and FcγRIII in triggering autoimmune arthritis.
Publisher
Rockefeller University Press
Subject
Immunology,Immunology and Allergy
Reference25 articles.
1. The IgG Fc receptor family;Gessner;Ann. Hematol.,1998
2. FcR γ chain deletion results in pleiotrophic effector cell defects;Takai;Cell.,1994
3. IgG-mediated enhancement of antibody responses is low in Fc receptor γ chain-deficient mice and increased in FcγRII-deficient mice;Wernersson;J. Immunol.,1999
4. Fc receptors initiate the Arthus reactionredefining the inflammatory cascade;Sylvestre;Science.,1994
5. Cytotoxic antibodies trigger inflammation through Fc receptors;Clynes;Immunity.,1995
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