Author:
Hiernaux J R,Jones J M,Rudbach J A,Rollwagen F,Baker P J
Abstract
CBA/N mice, which possess an X-linked immunodeficiency (xid), produce a convincing antibody response to lipopolysaccharide derived from Escherichia coli 0113 (LPS 0113), a thymus-independent antigen. The antibody response produced was shown to be specific for the O-polysaccharide moiety of LPS 0113, rather than lipid A or lipid-A-associated protein. The relevance of this finding to the nature of the genetic defect of xid-mice is discussed.
Publisher
Rockefeller University Press
Subject
Immunology,Immunology and Allergy
Cited by
16 articles.
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