Interferon beta 1, an intermediate in the tumor necrosis factor alpha-induced increased MHC class I expression and an autocrine regulator of the constitutive MHC class I expression.

Author:

Leeuwenberg J F1,van Damme J1,Jeunhomme G M1,Buurman W A1

Affiliation:

1. Department of Surgery, University of Limburg, Maastricht, The Netherlands.

Abstract

In conclusion, our observations indicate that the constitutive MHC class I expression is regulated by autocrine production of IFN-beta 1. TNF-alpha acts as an enhancer of the autocrine production of IFN-beta 1, and consequently as an enhancer of the MHC class I expression and viral protection.

Publisher

Rockefeller University Press

Subject

Immunology,Immunology and Allergy

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