Ontogeny of culture-generated suppressor cells.

Author:

Rollwagen F M,Stutman O

Abstract

Culture of murine lymphoid cells without added antigen results in the generation of cells which suppress a variety of in vitro immune responses, such as the mixed lymphocyte response (MLR) and the generation of alloreactive cytotoxic T cells (CTL). The ontogeny of this phenomenon was studied. Cells which suppressed the MLR after preculture were isolated from spleens and hematopoietic livers of fetal and young (less than 1 wk old) mice. On the other hand, the generation of alloreactive CTL could be suppressed only by precultured spleen cells taken from 1-w-old or older mice. The parallel between the development of the suppressor functions and the maturation of the responses they regulate, suggests a possible biological significance of the effect.

Publisher

Rockefeller University Press

Subject

Immunology,Immunology and Allergy

Cited by 18 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Development of Neonatal Th1/Th2 Function;International Reviews of Immunology;2000-01

2. Placental immunoregulatory factors;Journal of Reproductive Immunology;1987-03

3. Ontogeny of T Cells;Clinics in Immunology and Allergy;1985-06

4. CULTURE-GENERATED SUPPRESSOR CELLS;Transplantation;1985-05

5. Effect of reduced dietary protein intake on regulation of murine in vitro polyclonal T lymphocyte mitogenesis;Nutrition Research;1985-03

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