The half-life of RAG-1 protein in precursor B cells is increased in the absence of RAG-2 expression.

Author:

Grawunder U1,Schatz D G1,Leu T M1,Rolink A1,Melchers F1

Affiliation:

1. Basel Institute for Immunology, Switzerland.

Abstract

Site-specific recombination of immunoglobulin and T cell receptor gene segments in B and T lymphocytes is dependent on the expression of two recombinant activation genes, Rag-1 and Rag-2. Here, we show that RAG-1 protein turnover in pre-B cells depends on the expression of RAG-2. The apparent half-life of RAG-1 protein is increased when RAG-2 is not expressed in differentiating pre-B cells.

Publisher

Rockefeller University Press

Subject

Immunology,Immunology and Allergy

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