INDUCTION OF RABBIT ANTIBODY WITH MOLECULAR UNIFORMITY AFTER IMMUNIZATION WITH GROUP C STREPTOCOCCI

Author:

Eichmann Klaus1,Lackland Henry1,Hood Leroy1,Krause Richard M.1

Affiliation:

1. From The Rockefeller University, New York, 10021, and the National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014

Abstract

Antibodies with uniform properties may occur in rabbits after immunization with Group C streptococci. These precipitating antibodies possess specificity for the group-specific carbohydrate. Not uncommonly, their concentration is between 20 and 40 mg/ml of antiserum. Evidence for molecular uniformity in the case of one of these antibodies, described in detail here, includes: individual antigenic specificity; monodisperse distribution of the light chains by alkaline urea polyacrylamide disc electrophoresis; and a single amino acid in each of the first three N-terminal positions of the light chains. When the amino acid sequence of rabbit antibody b+ light chains (κ type) are aligned against their human κ counterparts, a definite homology is observed between the N-terminus of the human and the rabbit variable region.

Publisher

Rockefeller University Press

Subject

Immunology,Immunology and Allergy

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