Affiliation:
1. O.A.-W. and R.L.L. are at Human Oncology and Pathogenesis Program Leukemia Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY 10065
Abstract
Acute leukemias are clonal disorders of hematopoiesis wherein a leukemic stem cell (LSC) acquires mutations that confer the capacity for unlimited self-renewal, impaired hematopoietic differentiation, and enhanced proliferation to the leukemic clone. Many recent advances in understanding the biology of leukemia have come from studies defining specific genetic and epigenetic abnormalities in leukemic cells. Three recent articles, however, further our understanding of leukemia biology by elucidating specific abnormalities in metabolic pathways in leukemic hematopoiesis. These studies potentially converge on the concept that modulation of reactive oxygen species (ROS) abundance may influence the pathogenesis and treatment of acute myeloid leukemia (AML).
Publisher
Rockefeller University Press
Subject
Immunology,Immunology and Allergy
Cited by
66 articles.
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