Inflammatory dendritic cells—not basophils—are necessary and sufficient for induction of Th2 immunity to inhaled house dust mite allergen-Reference-Cited by-同舟云学术

Inflammatory dendritic cells—not basophils—are necessary and sufficient for induction of Th2 immunity to inhaled house dust mite allergen

Published:2010-09-06 Issue:10 Volume:207 Page:2097-2111
ISSN:1540-9538
Container-title:Journal of Experimental Medicine
language:en
Short-container-title:

Author:

Hammad Hamida¹,Plantinga Maud¹,Deswarte Kim¹,Pouliot Philippe¹,Willart Monique A.M.¹,Kool Mirjam¹,Muskens Femke²,Lambrecht Bart N.¹²

Affiliation:

1. Laboratory of Immunoregulation and Mucosal Immunology, Department of Respiratory Diseases, University of Ghent, 9000 Ghent, Belgium

2. Department of Pulmonary Medicine, Erasmus Medical Center, 3000 CA Rotterdam, Netherlands

Abstract

It is unclear how Th2 immunity is induced in response to allergens like house dust mite (HDM). Here, we show that HDM inhalation leads to the TLR4/MyD88-dependent recruitment of IL-4 competent basophils and eosinophils, and of inflammatory DCs to the draining mediastinal nodes. Depletion of basophils only partially reduced Th2 immunity, and depletion of eosinophils had no effect on the Th2 response. Basophils did not take up inhaled antigen, present it to T cells, or express antigen presentation machinery, whereas a population of FceRI+ DCs readily did. Inflammatory DCs were necessary and sufficient for induction of Th2 immunity and features of asthma, whereas basophils were not required. We favor a model whereby DCs initiate and basophils amplify Th2 immunity to HDM allergen.

Publisher

Rockefeller University Press

Subject

Immunology,Immunology and Allergy

Link

http://rupress.org/jem/article-pdf/207/10/2097/1202117/jem_20101563.pdf

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