Neutrophil phenotypes and functions in cancer: A consensus statement-Reference-Cited by-同舟云学术

Neutrophil phenotypes and functions in cancer: A consensus statement

Published:2022-05-06 Issue:6 Volume:219 Page:
ISSN:0022-1007
Container-title:Journal of Experimental Medicine
language:en
Short-container-title:

Author:

Quail Daniela F.¹^ORCID,Amulic Borko²^ORCID,Aziz Monowar³^ORCID,Barnes Betsy J.⁴⁵^ORCID,Eruslanov Evgeniy⁶^ORCID,Fridlender Zvi G.⁷^ORCID,Goodridge Helen S.⁸^ORCID,Granot Zvi⁹^ORCID,Hidalgo Andrés¹⁰¹¹^ORCID,Huttenlocher Anna¹²¹³^ORCID,Kaplan Mariana J.¹⁴^ORCID,Malanchi Ilaria¹⁵^ORCID,Merghoub Taha¹⁶¹⁷¹⁸¹⁹^ORCID,Meylan Etienne²⁰²¹^ORCID,Mittal Vivek²²²³^ORCID,Pittet Mikael J.²⁴²⁵²⁶²⁷^ORCID,Rubio-Ponce Andrea¹¹^ORCID,Udalova Irina A.²⁸^ORCID,van den Berg Timo K.²⁹³⁰^ORCID,Wagner Denisa D.³¹^ORCID,Wang Ping³^ORCID,Zychlinsky Arturo³²^ORCID,de Visser Karin E.³³³⁴³⁵^ORCID,Egeblad Mikala³⁶³⁵^ORCID,Kubes Paul³⁷³⁵³⁸³⁹^ORCID

Affiliation:

1. Rosalind and Morris Goodman Cancer Institute, Department of Physiology, McGill University, Montreal, Quebec, Canada

2. Cellular and Molecular Medicine, University of Bristol, Bristol, UK

3. Center for Immunology and Inflammation, Feinstein Institutes for Medical Research, Manhasset, NY

4. Center for Autoimmune, Musculoskeletal and Hematopoietic Diseases, Feinstein Institutes for Medical Research, Manhasset, NY

5. Departments of Molecular Medicine and Pediatrics, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY

6. Division of Thoracic Surgery, Department of Surgery, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA

7. Hadassah Medical Center, Institute of Pulmonary Medicine, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel

8. Board of Governors Regenerative Medicine Institute and Research Division of Immunology, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA

9. Department of Developmental Biology and Cancer Research, Hebrew University of Jerusalem, Jerusalem, Israel

10. Vascular Biology and Therapeutics Program and Department of Immunobiology, Yale University School of Medicine, New Haven, CT

11. Area of Cell and Developmental Biology, Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid, Spain

12. Department of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, WI

13. Department of Pediatrics, University of Wisconsin-Madison, Madison, WI

14. Systemic Autoimmunity Branch, Intramural Research Program, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD

15. Tumour-Host Interaction Laboratory, The Francis Crick Institute, London, UK

16. Ludwig Collaborative and Swim Across America Laboratory, Memorial Sloan Kettering Cancer Center, New York, NY

17. Parker Institute for Cancer Immunotherapy, Memorial Sloan Kettering Cancer Center, New York, NY

18. Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY

19. Weill Cornell Medical College, New York, NY

20. Lung Cancer and Immuno-Oncology Laboratory, Bordet Cancer Research Laboratories, Institut Jules Bordet, Université Libre de Bruxelles, Anderlecht, Belgium

21. Laboratory of Immunobiology, Université Libre de Bruxelles, Gosselies, Belgium

22. Department of Cardiothoracic Surgery, Neuberger Berman Foundation Lung Cancer Research Center, Weill Cornell Medicine, New York, NY

23. Department of Cell and Developmental Biology, Weill Cornell Medicine, New York, NY

24. Department of Pathology and Immunology, University of Geneva, Geneva, Switzerland

25. Ludwig Institute for Cancer Research, Lausanne Branch, Lausanne, Switzerland

26. Department of Oncology, Geneva University Hospitals, Geneva, Switzerland

27. AGORA Cancer Research Center, Lausanne, Switzerland

28. University of Oxford, Kennedy Institute of Rheumatology, Oxford, UK

29. Laboratory of Immunotherapy, Sanquin Research, Amsterdam, Netherlands

30. Department of Molecular Cell Biology and Immunology, Amsterdam University Medical Center, Amsterdam, Netherlands

31. Program in Cellular and Molecular Medicine, Division of Hematology/Oncology, Boston Children’s Hospital and Harvard Medical School, Boston, MA

32. Department of Cellular Microbiology, Max Planck Institute for Infection Biology, Berlin, Germany

33. Division of Tumour Biology and Immunology, Oncode Institute, Netherlands Cancer Institute, Amsterdam, Netherlands

34. Department of Immunohematology and Blood Transfusion, Leiden University Medical Centre, Leiden, Netherlands

35. Banbury Center meeting organizers, Diverse Functions of Neutrophils in Cancer, Cold Spring Harbor Laboratory, New York, NY

36. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY

37. Department of Pharmacology and Physiology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada

38. Department of Microbiology, Immunology & Infectious Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada

39. Calvin, Phoebe and Joan Snyder Institute for Chronic Diseases, University of Calgary, Calgary, Alberta, Canada

Abstract

Neutrophils are the first responders to infection and inflammation and are thus a critical component of innate immune defense. Understanding the behavior of neutrophils as they act within various inflammatory contexts has provided insights into their role in sterile and infectious diseases; however, the field of neutrophils in cancer is comparatively young. Here, we summarize key concepts and current knowledge gaps related to the diverse roles of neutrophils throughout cancer progression. We discuss sources of neutrophil heterogeneity in cancer and provide recommendations on nomenclature for neutrophil states that are distinct in maturation and activation. We address discrepancies in the literature that highlight a need for technical standards that ought to be considered between laboratories. Finally, we review emerging questions in neutrophil biology and innate immunity in cancer. Overall, we emphasize that neutrophils are a more diverse population than previously appreciated and that their role in cancer may present novel unexplored opportunities to treat cancer.

Funder

Cold Spring Harbor Laboratory

Canadian Institutes of Health Research

Terry Fox Research Institute

Canada Research Chair

Medical Research Council

National Institutes of Health

National Institute of Arthritis and Musculoskeletal and Skin Diseases

Department of Defense

National Cancer Institute

Israel Science Foundation

Sasson and Luisa Naor Fund