Macrophages and bone metastasis

Author:

Di Mitri Diletta12ORCID,Conforti Fabio3,Mantovani Alberto4567ORCID

Affiliation:

1. Department of Biomedical Sciences, Humanitas University 1 , Pieve Emanuele, Italy

2. Tumor microenvironment unit, IRCCS Humanitas Research Hospital 2 , Rozzano, Italy

3. Oncology Unit, Humanitas Gavazzeni 3 , Bergamo, Italy

4. Department of Biomedical Sciences, Humanitas University 4 , , Rozzano, Italy

5. Pieve Emanuele, Italy; IRCCS Humanitas Research Hospital 4 , , Rozzano, Italy

6. William Harvey Research Institute 5 , , London, UK

7. Queen Mary University 5 , , London, UK

Abstract

In the prostate bone metastasis microenvironment, macrophages activate a cascade that involves Activin A, the extracellular matrix, and SRC kinase and drives resistance to anti-androgen therapy. These findings (Li et al., 2023. J. Exp. Med.https://doi.org/10.1084/jem.20221007) have broad implications, including metastasis diversity in different tissue milieus and the interplay between hormones and immunity.

Publisher

Rockefeller University Press

Subject

Immunology,Immunology and Allergy

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