LIME-Reference-Cited by-同舟云学术

LIME

Published:2003-11-10 Issue:10 Volume:198 Page:1453-1462
ISSN:1540-9538
Container-title:Journal of Experimental Medicine
language:en
Short-container-title:

Author:

Brdičková Naděžda¹,Brdička Tomáš¹,Angelisová Pavla¹,Horváth Ondrej¹,Špička Jiří¹,Hilgert Ivan¹,Pačes Jan¹,Simeoni Luca²,Kliche Stefanie²,Merten Camilla²,Schraven Burkhart²,Hořejší Václav¹

Affiliation:

1. Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, 142 20 Prague 4, Czech Republic

2. Institute for Immunology, Otto-von-Guericke-University, 39120 Magdeburg, Germany

Abstract

Lymphocyte membrane rafts contain molecules critical for immunoreceptor signaling. Here, we report identification of a new raft-associated adaptor protein LIME (Lck-interacting molecule) expressed predominantly in T lymphocytes. LIME becomes tyrosine phosphorylated after cross-linking of the CD4 or CD8 coreceptors. Phospho-LIME associates with the Src family kinase Lck and its negative regulator, Csk. Ectopic expression of LIME in Jurkat T cells results in an increase of Csk in lipid rafts, increased phosphorylation of Lck and higher Ca2+ response to CD3 stimulation. Thus, LIME appears to be involved in regulation of T cell activation by coreceptors.

Publisher

Rockefeller University Press

Subject

Immunology,Immunology and Allergy

Link

http://rupress.org/jem/article-pdf/198/10/1453/1146969/jem198101453.pdf

Reference46 articles.

1. Raft membrane domains and immunoreceptor functions

2. Floating the Raft Hypothesis

3. The roles of membrane microdomains (rafts) in T cell activation

4. Different initiation of pre-TCR and γδTCR signalling

5. Lipid Raft Distribution of CD4 Depends on its Palmitoylation and Association with Lck, and Evidence for CD4-Induced Lipid Raft Aggregation as an Additional Mechanism to Enhance CD3 Signaling

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