Affiliation:
1. From the Departments of Pharmacology and Bacteriology, New York University College of Medicine, New York
Abstract
1. The mechanism of sensitization of the isolated frog' heart to a product of the hemolytic streptococcus has been investigated. The sensitization depends upon the release from the isolated heart of a substance which inhibits the action of the cardiotoxin. The inhibitor is released upon the first (sensitizing) administration of cardiotoxin, but not upon the second (contracture-producing) administration.
2. The inhibitor released by the heart neutralizes the lethal factor present in the streptococcal preparation employed.
3. Some of the properties of the inhibitor have been investigated.
Publisher
Rockefeller University Press
Subject
Immunology,Immunology and Allergy
Cited by
12 articles.
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