ANTIBODY-MEDIATED SUPPRESSION OF GRAFTED LYMPHOMA CELLS

Author:

Shin Hyun S.1,Kaliss Nathan1,Borenstein David1,Gately Maurice K.1

Affiliation:

1. From the Department of Microbiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, and The Jackson Laboratory, Bar Harbor, Maine 04609

Abstract

Specific alloantibody admixed with a grafted murine lymphoma is suppressive of the graft in mice of the inbred strain native to the tumor. Suppressive capacity of the host is obviated in mice given 500 R whole body irradiation before tumor inoculation but is restored when normal peritoneal macrophages are admixed with the tumor-antibody inoculum. Other normal cell types admixed with the tumor-antibody inoculum are not effective in restoring suppressive capacity.

Publisher

Rockefeller University Press

Subject

Immunology,Immunology and Allergy

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