Cc Chemokine Receptor 2 Is Critical for Induction of Experimental Autoimmune Encephalomyelitis

Author:

Fife Brian T.1,Huffnagle Gary B.2,Kuziel William A.3,Karpus William J.1

Affiliation:

1. Department of Pathology, Northwestern University Medical School, Chicago, Illinois 60611

2. Department of Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48109

3. Molecular Genetics and Microbiology, University of Texas, Austin, Texas 78712

Abstract

Experimental autoimmune encephalomyelitis (EAE) is a CD4+ T lymphocyte–mediated disease of the central nervous system (CNS) characterized by mononuclear cell infiltration, demyelination, and paralysis. We previously demonstrated a role for chemokines in acute and relapsing EAE pathogenesis. Presently, we investigated the role of CC chemokine receptor 2 (CCR2) in acute EAE. CCR2−/− mice did not develop clinical EAE or CNS histopathology, and showed a significant reduction in T cell– and CNS-infiltrating CD45highF4/80+ monocyte subpopulations. Peripheral lymphocytes from CCR2−/− mice produced comparable levels of interferon-gamma (IFN-γ) and interleukin (IL)-2 in response to antigen-specific restimulation when compared with control mice. Adoptively transferred myelin oligodendrocyte glycoprotein 35-55–specific T cells lacking expression of CCR2 were able to induce EAE, whereas CCR2−/− recipients of wild-type T cells failed to develop disease. These results suggest that CCR2 expression on host-derived mononuclear cells is critical for disease induction.

Publisher

Rockefeller University Press

Subject

Immunology,Immunology and Allergy

Reference28 articles.

1. Biotechnological agents for the immunotherapy of multiple sclerosis. Principles, problems, and perspectives;Hohlfeld;Brain.,1997

2. The central nervous system environment controls effector CD4+ T cell cytokine profile in experimental allergic encephalomyelitis;Krakowski;Eur. J. Immunol.,1997

3. T-lymphocyte entry into the central nervous system;Hickey;J. Neurosci. Res.,1991

4. Homing to central nervous system vasculature by antigen-specific lymphocytes. I. Localization of 14C-labeled cells during acute, chronic, and relapsing experimental allergic encephalomyelitis;Cross;Lab. Invest.,1990

5. Prevention of experimental autoimmune encephalomyelitis by antibodies against α4β1 integrin;Yednock;Nature.,1992

Cited by 462 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3