Active and latent forms of transforming growth factor beta activity in synovial effusions.-Reference-Cited by-同舟云学术

Active and latent forms of transforming growth factor beta activity in synovial effusions.

Published:1989-01-01 Issue:1 Volume:169 Page:291-296
ISSN:0022-1007
Container-title:Journal of Experimental Medicine
language:en
Short-container-title:

Author:

Fava R¹,Olsen N¹,Keski-Oja J¹,Moses H¹,Pincus T¹

Affiliation:

1. Department of Cell Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232.

Abstract

We have evaluated the possible involvement of TGF-beta in rheumatoid arthritis by assay of 16 cell-free synovial fluids for the presence of its active and "latent" forms. Evidence has been obtained for TGF-beta-like activity in synovial effusions by four criteria: (a) TGF-beta receptor competition, (b) soft-agar colony formation of AKR-2B and NRK-49F indicator cells, (c) immunological neutralization of the biological activity, and (d) biochemical activation of a latent form.

Publisher

Rockefeller University Press

Subject

Immunology,Immunology and Allergy

Link

http://rupress.org/jem/article-pdf/169/1/291/1098772/291.pdf

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