THE PREPARATION AND FUNCTION OF THE HYPERTENSIN-CONVERTING ENZYME

Author:

Skeggs Leonard T.1,Kahn Joseph R.1,Shumway Norman P.1

Affiliation:

1. From the Department of Medicine and Surgery, Veterans Administration Hospital, and the Department of Pathology, Western Reserve University, Cleveland

Abstract

It has been shown by use of isolated, perfused rat kidneys that hypertensin II is a potent vasoconstrictor substance while hypertensin I is not. Hence it would appear that in intact animals the pressor activity of hypertensin I results from its rapid conversion to hypertensin II. An enzyme which effects this conversion has been procured from horse plasma in a semipurified form by means of ammonium sulfate fractionation and isoelectric precipitation. A method is described for estimating the activity of the enzyme. An example of the use of the preparation in converting purified hypertensin I to hypertensin II has been described.

Publisher

Rockefeller University Press

Subject

Immunology,Immunology and Allergy

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