Affiliation:
1. From the Division of Experimental Pathology, Sloan-Kettering Institute for Cancer Research and Sloan-Kettering Division of the Cornell University Medical College, New York
Abstract
Rabbits were immunized with three highly purified macroglobulins, from patients with macroglobulinemia. The antisera reacted with two macroglobulins with sedimentation constants of 19S and 26S of homologous antigen, and cross-reacted with the 7S and 19S globulins of normal γ1-globulin and the heterologous pathological 19S macroglobulins. Exhaustive absorption of these antisera with normal γ-globulins rendered them specific for the homologous macroglobulins. The antigenic properties of the pathological macroglobulins indicate that these proteins are abnormal.
Publisher
Rockefeller University Press
Subject
Immunology,Immunology and Allergy
Cited by
59 articles.
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