Inhibition of the B Cell by CD22: A Requirement for Lyn-Reference-Cited by-同舟云学术

Inhibition of the B Cell by CD22: A Requirement for Lyn

Published:1998-03-02 Issue:5 Volume:187 Page:807-811
ISSN:0022-1007
Container-title:Journal of Experimental Medicine
language:en
Short-container-title:

Author:

Smith Kenneth G.C.¹,Tarlinton David M.¹,Doody Gina M.¹,Hibbs Margaret L.¹,Fearon Douglas T.¹

Affiliation:

1. From the Wellcome Trust Immunology Unit, Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge, England CB2 2SP; the Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Parkville, Victoria 3050, Australia; and the Ludwig Institute for Cancer Research, Tumour Biology Branch, Royal Melbourne Hospital, Victoria 3050, Australia

Abstract

Mice in which the Lyn, Cd22, or Shp-1 gene has been disrupted have hyperactive B cells and autoantibodies. We find that in the absence of Lyn, the ability of CD22 to become tyrosine phosphorylated after ligation of mIg, to recruit SHP-1, and to suppress mIg-induced elevation of intracellular [Ca2+] is lost. Therefore, Lyn is required for the SHP-1–mediated B cell suppressive function of CD22, accounting for similarities in the phenotypes of these mice.

Publisher

Rockefeller University Press

Subject

Immunology,Immunology and Allergy

Link

http://rupress.org/jem/article-pdf/187/5/807/1116078/97-2059.pdf

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