Metaplastic Cdx2-depleted cells can be very disruptive neighbors-Reference-Cited by-同舟云学术

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Metaplastic Cdx2-depleted cells can be very disruptive neighbors

Published:2018-02-12 Issue:3 Volume:215 Page:725-727
ISSN:0022-1007
Container-title:Journal of Experimental Medicine
language:en
Short-container-title:

Author:

Lourenço Filipe C.¹,Winton Douglas J.¹

Affiliation:

1. Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, England, UK

Abstract

In this issue of JEM, Balbinot et al. (https://doi.org/10.1084/jem.20170934) describe an original mechanism where Cdx2 inactivation regulates intestinal metaplastic to neoplastic transition in a paracrine fashion. Surprisingly, the target cells are neighboring “normal” Cdx2-positive cells.

Publisher

Rockefeller University Press

Subject

Immunology,Immunology and Allergy

Link

http://rupress.org/jem/article-pdf/215/3/725/1170471/jem_20180215.pdf

Reference13 articles.

1. The Cdx2 homeobox gene suppresses intestinal tumorigenesis through non–cell-autonomous mechanisms

2. Homeosis and intestinal tumours in Cdx2 mutant mice

3. An evolutionary perspective on field cancerization

4. Determination of axial polarity in the vertebrate embryo: Homeodomain proteins and homeogenetic induction

5. Metaplasia: tissue injury adaptation and a precursor to the dysplasia–cancer sequence

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