Small cell lung cancers made from scratch-Reference-Cited by-同舟云学术

Small cell lung cancers made from scratch

Published:2019-02-13 Issue:3 Volume:216 Page:476-478
ISSN:0022-1007
Container-title:Journal of Experimental Medicine
language:en
Short-container-title:

Author:

Gazdar Adi F.¹²,Minna John D.¹³

Affiliation:

1. Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, TX

2. Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX

3. Departments of Internal Medicine and Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX

Abstract

In this issue of JEM, Chen et al. (https://doi.org/10.1084/jem.20181155) describe a new approach for the transformation of human pluripotent embryonic stem cells (hESCs) into neuroendocrine (NE) tumors of the lung closely resembling human small cell lung cancer (SCLC). Another recent study uses a different method to transform fully differentiated normal human cells into high-grade NE tumors (Park et al. 2018. Science. https://doi.org/10.1126/science.aat5749). These approaches and their models provide important new resources for developing diagnostic, preventative, and therapeutic approaches for high-grade NE tumors.

Funder

National Cancer Institute

Publisher

Rockefeller University Press

Subject

Immunology,Immunology and Allergy

Link

http://rupress.org/jem/article-pdf/216/3/476/1171130/jem_20182216.pdf

Reference15 articles.

1. ASCL1 and NEUROD1 Reveal Heterogeneity in Pulmonary Neuroendocrine Tumors and Regulate Distinct Genetic Programs

2. Generation of pulmonary neuroendocrine cells and SCLC-like tumors from human embryonic stem cells

3. Genomic and Functional Fidelity of Small Cell Lung Cancer Patient-Derived Xenografts