THE MAINTENANCE OF A NORMAL PLASMA PROTEIN CONCENTRATION IN SPITE OF REPEATED PROTEIN LOSS BY BLEEDING

Author:

Barnett C. W.1,Jones R. B.1,Cohn R. B.1

Affiliation:

1. From the Department of Medicine, Stanford University Medical School, San Francisco

Abstract

1. Experiments on five dogs are described consisting in the daily removal of blood plasma in amount from 25 to 100 cc. the red cells being returned to the circulation in Locke's solution. In no case was there a significant drop in plasma protein concentration. 2. A gravimetric method for the determination of total plasma protein is described. 3. A case is reported of cirrhosis of the liver in which over 10 gm. of protein daily was lost in the ascitic fluid during a period of 7 months without any lowering of plasma protein concentration. 4. The constancy of the plasma protein level and the adequacy of the mechanism of regeneration is pointed out.

Publisher

Rockefeller University Press

Subject

Immunology,Immunology and Allergy

Cited by 17 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Gravimetric Estimation of Proteins Precipitated by Trichloroacetic Acid;Analytical Chemistry;1953-02-17

2. The Nephrotic Syndrome: Pathogenesis, Diagnosis and Treatment;Medical Clinics of North America;1952-07

3. HEPATIC FUNCTION DURING THE HYPOPROTEINEMIA OF RENAL DISEASE;Archives of Internal Medicine;1949-03-01

4. RENIN PROTEINURIA IN THE RAT;Journal of Experimental Medicine;1949-02-01

5. An experimental study of the relationship between plasma proteins and liver disturbance;The Journal of Pathology and Bacteriology;1949-01

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