Intestinal lamina propria dendritic cells maintain T cell homeostasis but do not affect commensalism

Author:

Welty Nathan E.1,Staley Christopher1,Ghilardi Nico2,Sadowsky Michael J.1,Igyártó Botond Z.1,Kaplan Daniel H.1

Affiliation:

1. Department of Dermatology, Center for Immunology and Department of Soil, Water, and Climate, Biotechnology Institute, University of Minnesota, Minneapolis, MN 55455

2. Department of Immunology, Genentech, South San Francisco, CA 94080

Abstract

Dendritic cells (DCs) in the intestinal lamina propria (LP) are composed of two CD103+ subsets that differ in CD11b expression. We report here that Langerin is expressed by human LP DCs and that transgenic human langerin drives expression in CD103+CD11b+ LP DCs in mice. This subset was ablated in huLangerin-DTA mice, resulting in reduced LP Th17 cells without affecting Th1 or T reg cells. Notably, cognate DC–T cell interactions were not required for Th17 development, as this response was intact in huLangerin-Cre I-Aβfl/fl mice. In contrast, responses to intestinal infection or flagellin administration were unaffected by the absence of CD103+CD11b+ DCs. huLangerin-DTA x BatF3−/− mice lacked both CD103+ LP DC subsets, resulting in defective gut homing and fewer LP T reg cells. Despite these defects in LP DCs and resident T cells, we did not observe alterations of intestinal microbial communities. Thus, CD103+ LP DC subsets control T cell homeostasis through both nonredundant and overlapping mechanisms.

Publisher

Rockefeller University Press

Subject

Immunology,Immunology and Allergy

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