A VIRUS DISEASE OF CATS, PRINCIPALLY CHARACTERIZED BY ALEUCOCYTOSIS, ENTERIC LESIONS AND THE PRESENCE OF INTRANUCLEAR INCLUSION BODIES

Author:

Hammon William D.1,Enders John F.1

Affiliation:

1. From the Department of Bacteriology and Immunology, The Harvard Medical School, Boston

Abstract

An acute, highly fatal epizootic disease of cats is described, which can be recognized by a fulminating and extreme leucopenia involving all types of white blood cells, aplasia of the bone marrow, including both the granulocytic and the erythrocytic series and occasionally the megakaryocytes, aplasia of lymphoid tissue, and characteristic intranuclear inclusion bodies in the cells of the intestinal mucosa and in certain cells of the spleen, lymph nodes and bone marrow. The infection has been induced in healthy cats by means of bacteria-free filtrates of emulsions of the spleen of infected animals. Collateral evidence supports the conclusion that the disease is due to a virus. The pathogenicity of the infectious agent has proved thus far to be strictly limited to the natural host.

Publisher

Rockefeller University Press

Subject

Immunology,Immunology and Allergy

Cited by 69 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Prophylactic Use of Antimicrobial Agents, and Antimicrobial Chemotherapy for the Neutropenic Patient;Antimicrobial Therapy in Veterinary Medicine;2013-08-16

2. Snapshot of Viral Infections in Wild Carnivores Reveals Ubiquity of Parvovirus and Susceptibility of Egyptian Mongoose to Feline Panleukopenia Virus;PLoS ONE;2013-03-20

3. Frequent Cross-Species Transmission of Parvoviruses among Diverse Carnivore Hosts;Journal of Virology;2012-12-05

4. A STUDY ON IN VITRO ISOLATION OF FELINE PANLEUKOPAENIA VIRUS;Acta Pathologica Microbiologica Scandinavica Section B Microbiology and Immunology;2009-08-15

5. HUMAN PARVOVIRUS B19;Feigin and Cherry's Textbook of Pediatric Infectious Diseases;2009

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