Development of Cd8α/α and Cd8α/β T Cells in Major Histocompatibility Complex Class I–Deficient Mice

Author:

Das Gobardhan1,Janeway Charles A.1

Affiliation:

1. Howard Hughes Medical Institute and Yale University Medical School, New Haven, Connecticut 06510

Abstract

Peripheral CD8+ T cells mainly use CD8α/β, and their development is mainly dependent on the major histocompatibility complex (MHC) class I proteins Kb and Db in H-2b mice. In this report, we have shown that the development of CD8α/β TCR-α/β cells in lymphoid organs as well as in intestinal intraepithelial lymphocytes (iIELs) is dependent on the MHC class I Kb and Db proteins. In contrast, TCR-α/β CD8α/α cells are found mainly in iIELs, and their numbers are unaffected in KbDb double knockout mice. Most of the TCR-γ/δ cells in the iIELs also bear CD8α/α, and they are also unaffected in KbDb −/− mice. In β2-microglobulin (β2m)-deficient mice, all of the TCR-α/β CD8α/α and CD8α/β T cells disappear, but TCR-γ/δ cells are unaffected by the absence of β2m.

Publisher

Rockefeller University Press

Subject

Immunology,Immunology and Allergy

Reference19 articles.

1. Major histocompatibility complex (MHC) class I KbDb −/− deficient mice possess functional CD8+ T cells and natural killer cells;Vugmeyster;Proc. Natl. Acad. Sci. USA,1998

2. β2-microglobulin deficient mice lack CD4−CD8+ cytolytic T cells;Zijlstra;Nature,1990

3. MHC class I-deficient mice;Raulet;Adv. Immunol,1994

4. TAP1 mutant mice are deficient in antigen presentation, surface class I molecules and CD4−CD8+ T cells;Van Kaer;Cell,1992

5. Phenotypic complexity of intraepithelial lymphocytes of the small intestine;Lefrancois;J. Immunol,1991

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