B Cell Development in the Spleen Takes Place in Discrete Steps and Is Determined by the Quality of B Cell Receptor–Derived Signals

Author:

Loder By Florienne1,Mutschler Bettina1,Ray Robert J.2,Paige Christopher J.2,Sideras Paschalis3,Torres Raul4,Lamers Marinus C.5,Carsetti Rita1

Affiliation:

1. From the Department of Molecular Immunology, Institute of Biology III, University of Freiburg, and the Max-Planck-Institute for Immunobiology, D-79108 Freiburg, Germany

2. Wellesley Hospital Research Institute, Toronto, Ontario M4Y 1J3, Canada

3. Department of Applied Cellular and Molecular Biology, Umeå University, S-901 87 Umeå, Sweden

4. Basel Institute for Immunology, 4005 Basel, Switzerland

5. Department of Developmental Immunology, Max-Planck-Institute for Immunobiology, D-79108 Freiburg, Germany

Abstract

Only mature B lymphocytes can enter the lymphoid follicles of spleen and lymph nodes and thus efficiently participate in the immune response. Mature, long-lived B lymphocytes derive from short-lived precursors generated in the bone marrow. We show that selection into the mature pool is an active process and takes place in the spleen. Two populations of splenic B cells were identified as precursors for mature B cells. Transitional B cells of type 1 (T1) are recent immigrants from the bone marrow. They develop into the transitional B cells of type 2 (T2), which are cycling and found exclusively in the primary follicles of the spleen. Mature B cells can be generated from T1 or T2 B cells.

Publisher

Rockefeller University Press

Subject

Immunology,Immunology and Allergy

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4. Microenvironmental organization and stromal cell associations of B lymphocyte precursor cells in mouse bone marrow;Jacobsen;Eur. J. Immunol.,1990

5. Peripheral B cell maturation. II. Heat-stable antigen(hi) splenic B cells are an immature developmental intermediate in the production of long-lived marrow-derived B cells;Allman;J. Immunol.,1993

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