STUDIES ON THE PATHOGENESIS OF FEVER

Author:

Kozak Marilyn Sue1,Hahn Helmut H.1,Lennarz William J.1,Wood W. Barry1

Affiliation:

1. From the Departments of Microbiology and Physiological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205

Abstract

Small quantities of highly purified granulocytic pyrogen have been separated from contaminating proteins by disc electrophoresis in polyacrylamide gel. The biologically active material thus isolated was shown to be electrophoretically homogeneous at pH 9 and pH 3.8. Earlier work on the chemical properties of the pyrogen molecule has been extended to include: (a) estimation of its molecular weight by gel filtration; (b) demonstration of free sulfhydryl groups essential for its biological activity; and (c) evidence that it is not inactivated by exhaustive extraction with ethanolether or n-heptane.

Publisher

Rockefeller University Press

Subject

Immunology,Immunology and Allergy

Cited by 36 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Synthesis, Processing, and Secretion of Plasma Proteins by the Liver and Other Organs and Their Regulation;The Plasma Proteins;1987

2. Rat endogenous pyrogen and fever;American Journal of Physiology-Regulatory, Integrative and Comparative Physiology;1986-05-01

3. Plasma protein and liver mRNA levels of two closely related murine α1-protease inhibitors during the acute phase reaction;Archives of Biochemistry and Biophysics;1985-05

4. Leukocytic Endogenous Mediator in Nonspecific Host Defenses;The Reticuloendothelial System;1985

5. Molecular mechanisms in endotoxin fever;Agents and Actions;1983-09

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