IMMUNOCHEMICAL STUDIES ON BLOOD GROUPS

Author:

Moreno Carlos1,Lundblad Arne1,Kabat Elvin A.1

Affiliation:

1. From the Departments of Microbiology, Neurology, and Human Genetics and Development, College of Physicians and Surgeons, Columbia University, and the Neurological Institute, Presbyterian Hospital, New York 10032

Abstract

The immunochemical properties of purified A1 and A2 glycoproteins have been compared to ascertain whether their antigenic determinants differ. Quantitative precipitin and complement-fixation studies using several anti-A sera as well as purified γG anti-A antibodies clearly showed a specificity difference. This was also supported by absorption studies: A2 substance specifically removed antibodies reacting with A2 substance leaving anti-A1 activity. A1 substance was more effective than A2 substance in dissolving an A1 anti-A1-specific precipitate. Purified γM anti-A hemolyzed A1 cells more readily than A2 cells. Inhibition studies using mono- and difucosyl type 2 A-active oligosaccharides showed that type 2 difucosyl receptors are present in A2 substance. The structural basis for the specificity difference between A1 and A2 would appear to be that A2 substances lack type 1 A determinants; this would account for the observed higher H and Leb activity in A2 substances.

Publisher

Rockefeller University Press

Subject

Immunology,Immunology and Allergy

Cited by 63 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Histo-Blood Group A Variants, O Variants, and Their Alleles;Handbook of Glycosyltransferases and Related Genes;2014

2. Blood Group Antigens;Comprehensive Glycoscience;2007

3. Blood Group A and H Determinants in Polyglycosyl Peptides of A1 and A2 Erythrocytes;European Journal of Biochemistry;2005-03-03

4. Histoblood Group A Variants, O Variants, and Their Alleles;Handbook of Glycosyltransferases and Related Genes;2002

5. ABO(H) System;Human Blood Groups;2000

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