Affiliation:
1. From the Department of Medicine, College of Physicians and Surgeons, Columbia University, and the Presbyterian Hospital, New York
Abstract
1. The evidence presented indicates that Mg++, or other cation such as Ca++, Ni++, or Co++, is essential for the hemolytic action of C'. Ca++, Ni++, and Co++ are less effective than Mg++. The hemolytic system usually does not contain sufficient Mg++ for optimal hemolytic activity so that a marked enhancement can be obtained by addition of extra Mg++.
2. The enhancing action of tissue fluids can be ascribed to their contribution of Mg++.
3. Substances which bind Mg++ and Ca++ are anticomplementary when added to the usual hemolytic system which contains only a small quantity of Mg++. This type of anticomplementary effect can be overcome by addition of extra Mg++.
4. Ca++ may also be essential to the lytic process but its action is much less pronounced than that of Mg++.
Publisher
Rockefeller University Press
Subject
Immunology,Immunology and Allergy
Cited by
249 articles.
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