Affiliation:
1. From the Department of Surgery, The University of Chicago, and the Argonne National Laboratory, Chicago
Abstract
When the entire body of dogs was exposed to 450 units of Roentgen irradiation a hemorrhagic syndrome developed which was characterized by thrombo-cytopenia, prolonged clotting and bleeding times, and neutropenia.
The prothrombin time remained normal until about 24 hours before death. The calcium, phosphorus, and magnesium levels were not altered. Fibrinogen was present but syneresis was poor.
Toluidine blue and protamine sulfate, substances which can inhibit the biologic action of heparin, restored the clotting time to normal.
The hemorrhagic state was not materially altered by transfusions, vitamin K, or vitamin C.
Toluidine blue and protamine sulfate were ineffective in the control of hemorrhage produced by dicumarol.
The defect responsible for bleeding after irradiation appeared to be the presence in the circulation of an anticoagulant whose properties, so far as tested, were indistinguishable from those of heparin.
Publisher
Rockefeller University Press
Subject
Immunology,Immunology and Allergy
Cited by
73 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献
1. Protamine for Intravenous Use in Man and in Animal Experiments;Acta Medica Scandinavica;2009-04-24
2. Blood Clotting and Related Processes;Advances in Enzymology - and Related Areas of Molecular Biology;2006-11-22
3. The radiation syndromes;Handbuch der Medizinischen Radiologie / Encyclopedia of Medical Radiology;1972
4. Die Beeinflussung der experimentellen Glomerulonephritis durch Heparin und Prednisolon;Klinische Wochenschrift;1970-02
5. Hemopoietic System;Differential Diagnosis of Internal Diseases;1967