THE RELATION OF THE PNEUMOCOCCUS TO HYDROGEN ION CONCENTRATION, ACID DEATH-POINT, AND DISSOLUTION OF THE ORGANISM

Author:

Lord Frederick T.1,Nye Robert N.1

Affiliation:

1. From the Research Laboratory of the Massachusetts General Hospital, Boston.

Abstract

1. In the growth and death of the pneumococcus in fluid media containing 1 per cent glucose the production of acid is the most important bactericidal factor. 2. 1 per cent glucose bouillon cultures of the pneumococcus allowed to grow and die out usually reach a final acidity of a pH of about 5.1. 3. At a hydrogen ion concentration of about 5.1 or higher, the pneumococcus does not survive longer than a few hours. 4. In hydrogen ion concentrations of about 6.8 to 7.4 the pneumococcus may live for at least many days. 5. In the intervening hydrogen ion concentrations, between 6.8 and 5.1, the pneumococcus is usually killed with a rapidity which bears a direct relation to the hydrogen ion concentration; i.e., the greater the acidity the more rapid is the death. 6. Cloudy suspensions of washed pneumococci in hydrogen ion concentrations varying from 8.0 to 4.0 show, after incubation, dissolution of organisms in lower hydrogen ion concentrations than about 5.0. This dissolution is most marked at about 5.0 to 6.0. Some dissolution also takes place toward the more alkaline end of the scale. No dissolution occurs at the most acid end of the scale.

Publisher

Rockefeller University Press

Subject

Immunology,Immunology and Allergy

Cited by 18 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Molecular Control of Bacterial Death and Lysis;Microbiology and Molecular Biology Reviews;2008-03

2. Nonoxidative Antimicrobial Reactions of Leukocytes;Regulation of Leukocyte Function;1984

3. Activites Bactériolytiques des Microorganismes;Ergebnisse der Mikrobiologie, Immunitätsforschung und experimentellen Therapie;1957

4. STUDIES ON THE MECHANISM OF IMMUNITY IN TUBERCULOSIS;Journal of Experimental Medicine;1939-04-01

5. THE EFFECTS OF ACIDITY UPON THE GROWTH OF PNEUMOCOCCUS IN CULTURE MEDIA CONTAINING PROTEINS;Journal of Experimental Medicine;1938-05-01

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