Lipid metabolism and cancer-Reference-Cited by-同舟云学术

Lipid metabolism and cancer

Published:2020-12-18 Issue:1 Volume:218 Page:
ISSN:0022-1007
Container-title:Journal of Experimental Medicine
language:en
Short-container-title:

Author:

Bian Xueli¹^ORCID,Liu Rui²^ORCID,Meng Ying³^ORCID,Xing Dongming¹⁴^ORCID,Xu Daqian³^ORCID,Lu Zhimin³⁵^ORCID

Affiliation:

1. Cancer Institute of The Affiliated Hospital of Qingdao University and Qingdao Cancer Institute, Qingdao, China

2. State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, Sichuan University, Chengdu, China

3. Zhejiang Provincial Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, and Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, China

4. School of Life Sciences, Tsinghua University, Beijing, China

5. Zhejiang University Cancer Center, Hangzhou, China

Abstract

Dysregulation in lipid metabolism is among the most prominent metabolic alterations in cancer. Cancer cells harness lipid metabolism to obtain energy, components for biological membranes, and signaling molecules needed for proliferation, survival, invasion, metastasis, and response to the tumor microenvironment impact and cancer therapy. Here, we summarize and discuss current knowledge about the advances made in understanding the regulation of lipid metabolism in cancer cells and introduce different approaches that have been clinically used to disrupt lipid metabolism in cancer therapy.

Funder

Zhejiang University

Leading Innovative and Entrepreneur Team Introduction Program of Zhejiang

National Natural Science Foundation of China

Qingdao Postdoctoral Application Research Project

China Postdoctoral Science Foundation

Ministry of Science and Technology of the People's Republic of China

Publisher

Rockefeller University Press

Subject

Immunology,Immunology and Allergy

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