Tumor-infiltrating dendritic cell states are conserved across solid human cancers

Author:

Gerhard Genevieve M.1ORCID,Bill Ruben1ORCID,Messemaker Marius1ORCID,Klein Allon M.2ORCID,Pittet Mikael J.134ORCID

Affiliation:

1. Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA

2. Department of Systems Biology, Harvard Medical School, Boston, MA

3. Department of Pathology and Immunology, University of Geneva, Geneva, Switzerland

4. Department of Oncology, Geneva University Hospitals, Geneva, Switzerland

Abstract

Dendritic cells (DCs) contribute a small fraction of the tumor microenvironment but are emerging as an essential antitumor component based on their ability to foster T cell immunity and immunotherapy responses. Here, we discuss our expanding view of DC heterogeneity in human tumors, as revealed with meta-analysis of single-cell transcriptome profiling studies. We further examine tumor-infiltrating DC states that are conserved across patients, cancer types, and species and consider the fundamental and clinical relevance of these findings. Finally, we provide an outlook on research opportunities to further explore mechanisms governing tumor-infiltrating DC behavior and functions.

Funder

Massachusetts General Hospital

National Institutes of Health

Swiss National Science Foundation

ISREC Foundation

Publisher

Rockefeller University Press

Subject

Immunology,Immunology and Allergy

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