Affiliation:
1. Department of Immunology, Duke University Medical Center, Durham, NC
Abstract
In this issue of JEM, Wu et al. (https://doi.org/10.1084/jem.20200412) provide new insights into allelic exclusion. They demonstrate that Vβ-to-DβJβ rearrangement occurs stochastically on two competing Tcrb alleles, with suboptimal Vβ recombination signal sequences limiting synchronous rearrangements and essential for allelic exclusion.
Funder
National Institutes of Health
Publisher
Rockefeller University Press
Subject
Immunology,Immunology and Allergy