HLA-E–dependent Presentation of Mtb-derived Antigen to Human CD8+ T Cells-Reference-Cited by-同舟云学术

HLA-E–dependent Presentation of Mtb-derived Antigen to Human CD8+ T Cells

Published:2002-11-25 Issue:11 Volume:196 Page:1473-1481
ISSN:1540-9538
Container-title:Journal of Experimental Medicine
language:en
Short-container-title:

Author:

Heinzel Amy S.¹,Grotzke Jeff E.¹²,Lines Rebecca A.³,Lewinsohn Deborah A.³²,McNabb Andria L.⁴,Streblow Daniel N.²,Braud Veronique M.⁵,Grieser Heather J.⁶,Belisle John T.⁶,Lewinsohn David M.¹²

Affiliation:

1. Division of Pulmonary & Critical Care Medicine, Portland VA Medical Center, the

2. Dept. of Molecular Microbiology and Immunology, Oregon Health Sciences University, Portland, OR 97201

3. Division of Pediatrics, Oregon Health Sciences University, Portland, OR 97201

4. Corixa Corporation, Seattle, WA 98104

5. Institut de Pharmacologie Moléculaire et Cellulaire, CNRS Sophia Antipolis, 06560 Paris, France

6. Mycobacteria Research Laboratories, Dept. of Microbiology, Colorado State University, Fort Collins, CO 80523

Abstract

Previous studies in mice and humans have suggested an important role for CD8+ T cells in host defense to Mtb. Recently, we have described human, Mtb-specific CD8+ cells that are neither HLA-A, B, or C nor group 1 CD1 restricted, and have found that these cells comprise the dominant CD8+ T cell response in latently infected individuals. In this report, three independent methods are used to demonstrate the ability of these cells to recognize Mtb-derived antigen in the context of the monomorphic HLA-E molecule. This is the first demonstration of the ability of HLA-E to present pathogen-derived antigen. Further definition of the HLA-E specific response may aid development of an effective vaccine against tuberculosis.

Publisher

Rockefeller University Press

Subject

Immunology,Immunology and Allergy

Link

http://rupress.org/jem/article-pdf/196/11/1473/1141342/jem196111473.pdf

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