Author:
Webb S R,Li J H,MacNeil I,Marrack P,Sprent J,Wilson D B
Abstract
Previous studies have shown that T cell clones specific for strong Mlsa,d determinants concomitantly display apparently random reactivity to allo-H-2 determinants. One explanation for this finding is that T cell recognition of Mlsa,d and allo-H-2 determinants is controlled by separate sets of receptors. If these receptors were chromosomally unlinked, karyotypically unstable T cell hybrids with dual reactivity for Mlsa,d and particular allo-H-2 determinants would be expected, occasionally, to lose reactivity for one set of determinants, but not the other. The results presented here provide direct support for this prediction.
Publisher
Rockefeller University Press
Subject
Immunology,Immunology and Allergy
Cited by
25 articles.
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