STUDIES ON THE MECHANISM OF THE SHWARTZMAN PHENOMENON

Author:

Lee Leung1,Stetson Chandler A.1

Affiliation:

1. From the Department of Pathology, New York University College of Medicine, New York

Abstract

Rabbits given single injections of endotoxin and then skin-tested with endotoxin from 1 day to 1 month later exhibit accelerated skin reactions resembling the Arthus phenomenon. Injection of one endotoxin alters the subsequent reactivity of rabbits to other endotoxins as well. The state of altered reactivity can be transferred with serum, and appears to be related to the presence of non-precipitating cross-reactive antibody, rather than to specific precipitating antibody.

Publisher

Rockefeller University Press

Subject

Immunology,Immunology and Allergy

Cited by 35 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Challenges of using lipopolysaccharides for cancer immunotherapy and potential delivery-based solutions thereto;Therapeutic Delivery;2019-03

2. Lipid A-induced tolerance and hyperreactivity to hypothermia in mice;Infection and Immunity;1978-02

3. Opposing Effects of Immunity to Endotoxin: Hypersensitivity Versus Protection;Gram-Negative Bacterial Infections and Mode of Endotoxin Actions;1975

4. Vasculitis allergica;Vorträge des VII. Fortbildungskurses der Dermatologischen Klinik und Poliklinik der Universität München in Verbindung mit dem Verband der Niedergelassenen Dermatologen Deutschlands e.V. vom 22. bis 27. Juli 1973;1973

5. Dermal Reactions to Endotoxins in Calves: their Significance in the Pathogenesis of Colibacillosis;Research in Veterinary Science;1972-11

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