SUPPRESSION OF EXPERIMENTAL "ALLERGIC" ENCEPHALOMYELITIS IN GUINEA PIGS BY ENCEPHALITOGENIC PROTEINS EXTRACTED FROM HOMOLOGOUS BRAIN-Reference-Cited by-同舟云学术

SUPPRESSION OF EXPERIMENTAL "ALLERGIC" ENCEPHALOMYELITIS IN GUINEA PIGS BY ENCEPHALITOGENIC PROTEINS EXTRACTED FROM HOMOLOGOUS BRAIN

Published:1960-02-01 Issue:2 Volume:111 Page:171-180
ISSN:1540-9538
Container-title:Journal of Experimental Medicine
language:en
Short-container-title:

Author:

Shaw Cheng-Mei¹,Fahlberg Willson J.¹,Kies Marian W.¹,Alvord Ellsworth C.¹

Affiliation:

1. From the Departments of Neurology, Pathology, and Microbiology, Baylor University College of Medicine, Houston, and the Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland

Abstract

The intradermal injection of aqueous solutions of certain homologous neural proteins will suppress the encephalomyelitis which is induced in guinea pigs by the previous injection of whole homologous brain with Freund's adjuvants. These neural proteins extracted by dilute acid from defatted guinea pig brain are themselves highly encephalitogenic when injected with adjuvants, but the specificity of this suppression for encephalitogenic as compared to non-encephalitogenic extracts remains to be proven. Suppression is probably not due to a non-specific stress reaction, as indicated by the absence of suppression by intradermal injections of alcohol and by statistically insignificant and inconstant effects of similar injections of tuberculin.

Publisher

Rockefeller University Press

Subject

Immunology,Immunology and Allergy

Link

http://rupress.org/jem/article-pdf/111/2/171/1079859/171.pdf

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